| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50229193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Flag Assay |
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| IC50 | 6±n/a nM |
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| Citation |  Harrington, P; Heidebrecht, Jr., RW; Kattar, S; Miller, TA; Otte, KM; Siliphaivanh, P; Stanton, MG; Tempest, P; Wilson, KJ; Witter, DJ 4-carboxybenzylamino derivatives as histone deacetylase inhibitors US Patent US9096559 Publication Date 8/4/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50229193 |
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| n/a |
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| Name | BDBM50229193 |
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| Synonyms: | CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N3O3S |
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| Mol. Mass. | 381.448 |
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| SMILES | COC(=O)NCc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1 |
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| Structure | 
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