| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-secretory ribonuclease |
|---|
| Ligand | BDBM173620 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Ribonuclease Activity Assay |
|---|
| Temperature | 303.15±n/a K |
|---|
| Ki | 2.083e+5± 2.68e+4 nM |
|---|
| IC50 | 2.821e+5± 4.7e+3 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Chatzileontiadou, DS; Parmenopoulou, V; Manta, S; Kantsadi, AL; Kylindri, P; Griniezaki, M; Kontopoulou, F; Telopoulou, A; Prokova, H; Panagopoulos, D; Boix, E; Balatsos, NA; Komiotis, D; Leonidas, DD Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem63:152-65 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-secretory ribonuclease |
|---|
| Name: | Non-secretory ribonuclease |
|---|
| Synonyms: | EDN | Eosinophil-derived neurotoxin (EDN) | Non-secretory ribonuclease | RNAS2_HUMAN | RNASE2 | RNAse 2 | RNS2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 18364.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 161 |
|---|
| Sequence: | MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNY
QRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNI
SNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
|
|
|
|---|
| BDBM173620 |
|---|
| n/a |
|---|
| Name | BDBM173620 |
|---|
| Synonyms: | 1-[(2R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione (VI) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H11FN2O6 |
|---|
| Mol. Mass. | 262.1918 |
|---|
| SMILES | OC[C@H]1O[C@H](C(O)[C@H]1O)n1cc(F)c(=O)[nH]c1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
