| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuraminidase |
|---|
| Ligand | BDBM5249 |
|---|
| Substrate/Competitor | BDBM4702 |
|---|
| Meas. Tech. | Neuraminidase Inhibition Assay |
|---|
| pH | 6.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Lew, W; Escarpe, PA; Mendel, DB; Sweeny, DJ; Kim, CU Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity. Bioorg Med Chem Lett9:2811-4 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Neuraminidase |
|---|
| Name: | Neuraminidase |
|---|
| Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 50124.14 |
|---|
| Organism: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
|---|
| Description: | P03468 |
|---|
| Residue: | 454 |
|---|
| Sequence: | MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
|
|
|
|---|
| BDBM5249 |
|---|
| BDBM4702 |
|---|
| Name | BDBM5249 |
|---|
| Synonyms: | (3R,4R,5S)-5-amino-4-acetamido-3-{[(3S)-1-hydroxypentan-3-yl]oxy}cyclohex-1-ene-1-carboxylic acid | carbocyclic analog 20 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H24N2O5 |
|---|
| Mol. Mass. | 300.3508 |
|---|
| SMILES | [H][C@](CC)(CCO)O[C@@H]1C=C(C[C@H](N)[C@H]1NC(C)=O)C(O)=O |r,c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
