Reaction Details |
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Target | Neuraminidase |
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Ligand | BDBM5259 |
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Substrate/Competitor | BDBM4702 |
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Meas. Tech. | Neuraminidase Inhibition Assay |
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pH | 6.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 51±n/a nM |
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Citation | Lew, W; Wu, H; Chen, X; Graves, BJ; Escarpe, PA; MacArthur, HL; Mendel, DB; Kim, CU Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity. Bioorg Med Chem Lett10:1257-60 (2000) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Neuraminidase |
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Name: | Neuraminidase |
Synonyms: | Influenza A Virus Neuraminidase | NA | NRAM_I34A1 | Neuraminidase | Neuraminidase A |
Type: | Enzyme |
Mol. Mass.: | 50124.14 |
Organism: | Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(H1N1)) |
Description: | P03468 |
Residue: | 454 |
Sequence: | MNPNQKIITIGSICLVVGLISLILQIGNIISIWISHSIQTGSQNHTGICNQNIITYKNST
WVKDTTSVILTGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLT
QGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGI
SGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECACVNGSCFTIMTDGPSDGLASYKI
FKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIG
YICSGVFGDNPRPEDGTGSCGPVYVDGANGVKGFSYRYGNGVWIGRTKSHSSRHGFEMIW
DPNGWTETDSKFSVRQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPKEKT
IWTSASSISFCGVNSDTVDWSWPDGAELPFSIDK
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BDBM5259 |
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BDBM4702 |
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Name | BDBM5259 |
Synonyms: | (3R,4R,5S)-5-amino-4-acetamido-3-(4-methylpiperidin-1-yl)cyclohex-1-ene-1-carboxylic acid | C3-Cyclic Amine Carbocyclic Analogue 4j |
Type | Small organic molecule |
Emp. Form. | C15H25N3O3 |
Mol. Mass. | 295.3773 |
SMILES | CC1CCN(CC1)[C@@H]1C=C(C[C@H](N)[C@H]1NC(C)=O)C(O)=O |r,c:9| |
Structure |
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