Ki Summary

Reaction Details

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Target

MAP kinase-activated protein kinase 2

Ligand

BDBM175242

Substrate/Competitor

n/a

Meas. Tech.

IMAP Assay

7.5±n/a

IC50

21±n/a nM

Comments

extracted

Citation

Hockerman, SL; Monahan, JB; Selness, SR Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds US Patent US9115089 Publication Date 8/25/2015

More Info.:

Get all data from this article, Assay Method

MAP kinase-activated protein kinase 2

Name:

MAP kinase-activated protein kinase 2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

45579.87

Organism:

Homo sapiens (Human)

Description:

P49137

Residue:

400

Sequence:

MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH

BDBM175242

n/a

Name

BDBM175242

Synonyms:

US11844801, Compound (M)-I | US9115089, 49

Type

Small organic molecule

Emp. Form.

C25H22ClF2N5O3

Mol. Mass.

513.924

SMILES

Cc1cnc(cc1-n1c(C)cc(OCc2ncc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O |(3.33,-1.54,;2,-2.31,;2,-3.85,;.67,-4.62,;-.67,-3.85,;-.67,-2.31,;.67,-1.54,;.67,,;2,.77,;3.33,,;2,2.31,;.67,3.08,;.67,4.62,;2,5.39,;3.33,4.62,;3.33,3.08,;4.67,2.31,;6,3.08,;7.34,2.31,;6,4.62,;4.67,5.39,;4.67,6.93,;-.67,2.31,;-2,3.08,;-.67,.77,;-2,,;-2,-4.62,;-2,-6.16,;-3.33,-6.93,;-4.67,-6.16,;-4.67,-4.62,;-3.33,-3.85,;-6,-3.85,;-6.77,-2.52,;-5.23,-2.52,;-7.34,-4.62,)|

Structure