Ki Summary

Reaction Details

Report a problem with these data

Target

Protein Nef

Ligand

BDBM288019

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Antiviral (HIV-1) Activity

Temperature

298.15±n/a K

EC50

3.10±n/a nM

Comments

extracted

Citation

Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018

More Info.:

Get all data from this article, Assay Method

Protein Nef

Name:

Protein Nef

Synonyms:

Type:

C-terminal core protein

Mol. Mass.:

23340.47

Organism:

Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)

Description:

P03406

Residue:

206

Sequence:

MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC

BDBM288019

n/a

Name

BDBM288019

Synonyms:

US10087178, Example 1

Type

Small organic molecule

Emp. Form.

C21H21ClFN3O5

Mol. Mass.

449.86

SMILES

CO[C@H]1C[C@@]2(C1)CN(C)C(=O)c1c(O)c(=O)c(cn21)C(=O)NCc1cccc(Cl)c1F |r,wU:4.4,wD:2.1,(5.33,-4.55,;4,-3.78,;4,-2.24,;5.09,-1.15,;4,-.07,;2.91,-1.15,;5.33,.7,;5.33,2.24,;6.67,3.01,;4,3.01,;4,4.55,;2.67,2.24,;1.33,3.01,;1.33,4.55,;,2.24,;-1.33,3.01,;,.7,;1.33,-.07,;2.67,.7,;-1.33,-.07,;-1.33,-1.61,;-2.67,.7,;-4,-.07,;-5.33,.7,;-5.33,2.24,;-6.67,3.01,;-8,2.24,;-8,.7,;-9.34,-.07,;-6.67,-.07,;-6.67,-1.61,)|

Structure