Reaction Details | |||
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Target | Protein Nef | ||
Ligand | BDBM288024 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Measurement of Antiviral (HIV-1) Activity | ||
Temperature | 298.15±n/a K | ||
EC50 | 2.00±n/a nM | ||
Comments | extracted | ||
Citation | Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Nef | |||
Name: | Protein Nef | ||
Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef | ||
Type: | C-terminal core protein | ||
Mol. Mass.: | 23340.47 | ||
Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) | ||
Description: | P03406 | ||
Residue: | 206 | ||
Sequence: |
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BDBM288024 | |||
n/a | |||
Name | BDBM288024 | ||
Synonyms: | US10087178, Example 6 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23ClFN3O5 | ||
Mol. Mass. | 463.887 | ||
SMILES | CCN1C(=O)c2c(O)c(=O)c(cn2C[C@]11C[C@@H](C1)OC)C(=O)NCc1cccc(Cl)c1F |r,wU:16.20,wD:14.19,(8,2.24,;6.67,3.01,;5.33,2.24,;4,3.01,;4,4.55,;2.67,2.24,;1.33,3.01,;1.33,4.55,;,2.24,;-1.33,3.01,;,.7,;1.33,-.07,;2.67,.7,;4,-.07,;5.33,.7,;5.81,-.76,;7.34,-.92,;6.87,.54,;8.54,-1.89,;8.3,-3.41,;-1.33,-.07,;-1.33,-1.61,;-2.67,.7,;-4,-.07,;-5.33,.7,;-5.33,2.24,;-6.67,3.01,;-8,2.24,;-8,.7,;-9.34,-.07,;-6.67,-.07,;-6.67,-1.61,)| | ||
Structure |