| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Nef |
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| Ligand | BDBM288028 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Measurement of Antiviral (HIV-1) Activity |
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| Temperature | 298.15±n/a K |
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| EC50 | 5.60±n/a nM |
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| Comments | extracted |
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| Citation |  Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Nef |
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| Name: | Protein Nef |
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| Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef |
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| Type: | C-terminal core protein |
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| Mol. Mass.: | 23340.47 |
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| Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) |
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| Description: | P03406 |
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| Residue: | 206 |
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| Sequence: | MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC
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| BDBM288028 |
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| n/a |
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| Name | BDBM288028 |
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| Synonyms: | US10087178, Example 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F2N3O5 |
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| Mol. Mass. | 447.4319 |
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| SMILES | CC(C)N1C[C@@]2(C[C@@H]2CO)n2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O |r| |
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| Structure | 
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