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TargetProtein Nef
LigandBDBM288038
Substrate/Competitorn/a
Meas. Tech.Measurement of Antiviral (HIV-1) Activity
Temperature298.15±n/a K
EC50 4.20±n/a nM
Commentsextracted
Citation Miyazaki, SIsoshima, HOshita, KKawashita, SNagahashi, NTerashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018
More Info.:Get all data from this article,  Assay Method
 
Protein Nef
Name:Protein Nef
Synonyms:3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef
Type:C-terminal core protein
Mol. Mass.:23340.47
Organism:Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Description:P03406
Residue:206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC
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BDBM288038
n/a
NameBDBM288038
Synonyms:US10087178, Example 19
TypeSmall organic molecule
Emp. Form.C24H26F2N4O5
Mol. Mass.488.4838
SMILESCC(C)N1C[C@@]2(C[C@@H]2C(=O)N(C)C)n2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O |r|
Structure
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