Ki Summary

Reaction Details

Report a problem with these data

Target

Protein Nef

Ligand

BDBM288052

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Antiviral (HIV-1) Activity

Temperature

298.15±n/a K

EC50

23.0±n/a nM

Comments

extracted

Citation

Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018

More Info.:

Get all data from this article, Assay Method

Protein Nef

Name:

Protein Nef

Synonyms:

Type:

C-terminal core protein

Mol. Mass.:

23340.47

Organism:

Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)

Description:

P03406

Residue:

206

Sequence:

MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC

BDBM288052

n/a

Name

BDBM288052

Synonyms:

N-(2,4-difluorobenzyl)-cis- 3,9'-dihydroxy-2'-methyl- 1',8'-dioxo-1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazine]- 7'-carboxamide hydrobromide | US10087178, Example S12

Type

Small organic molecule

Emp. Form.

C20H19F2N3O5

Mol. Mass.

419.3788

SMILES

CN1C[C@]2(C[C@H](O)C2)n2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O |r,wU:3.7,wD:5.5,(8,2.63,;6.67,1.86,;6.67,.32,;5.33,-.45,;6.42,-1.54,;5.33,-2.63,;5.33,-4.17,;4.25,-1.54,;4,.32,;2.67,-.45,;1.33,.32,;,-.45,;,-1.99,;-1.33,.32,;-2.67,-.45,;-4,.32,;-4,1.86,;-5.33,2.63,;-6.67,1.86,;-8,2.63,;-6.67,.32,;-5.33,-.45,;-5.33,-1.99,;1.33,1.86,;,2.63,;2.67,2.63,;2.67,4.17,;4,1.86,;5.33,2.63,;5.33,4.17,)|

Structure