Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Protein Nef | ||
Ligand | BDBM288059 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Measurement of Antiviral (HIV-1) Activity | ||
Temperature | 298.15±n/a K | ||
EC50 | 4.80±n/a nM | ||
Comments | extracted | ||
Citation | Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Nef | |||
Name: | Protein Nef | ||
Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef | ||
Type: | C-terminal core protein | ||
Mol. Mass.: | 23340.47 | ||
Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) | ||
Description: | P03406 | ||
Residue: | 206 | ||
Sequence: |
| ||
BDBM288059 | |||
n/a | |||
Name | BDBM288059 | ||
Synonyms: | N-(2,4-difluorobenzyl)-2'- ethyl-9'-hydroxy-trans-3- methoxy-1',8'-dioxo- 1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazine]- 7'-carboxamide hydrochloride | US10087178, Example S19 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23F2N3O5 | ||
Mol. Mass. | 447.4319 | ||
SMILES | CCN1C[C@@]2(C[C@@H](C2)OC)n2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O |r,wU:4.4,6.8,(8.67,2.24,;7.34,3.01,;6,2.24,;6,.7,;4.67,-.07,;3.58,-1.15,;4.67,-2.24,;5.76,-1.15,;4.67,-3.78,;6,-4.55,;3.33,.7,;2,-.07,;.67,.7,;-.67,-.07,;-.67,-1.61,;-2,.7,;-3.33,-.07,;-4.67,.7,;-4.67,2.24,;-6,3.01,;-7.34,2.24,;-8.67,3.01,;-7.34,.7,;-6,-.07,;-6,-1.61,;.67,2.24,;-.67,3.01,;2,3.01,;2,4.55,;3.33,2.24,;4.67,3.01,;4.67,4.55,)| | ||
Structure |