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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein Nef | ||
| Ligand | BDBM288063 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Measurement of Antiviral (HIV-1) Activity | ||
| Temperature | 298.15±n/a K | ||
| EC50 | 6.30±n/a nM | ||
| Comments | extracted | ||
| Citation |  Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein Nef | |||
| Name: | Protein Nef | ||
| Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef | ||
| Type: | C-terminal core protein | ||
| Mol. Mass.: | 23340.47 | ||
| Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) | ||
| Description: | P03406 | ||
| Residue: | 206 | ||
| Sequence: |
| ||
| BDBM288063 | |||
| n/a | |||
| Name | BDBM288063 | ||
| Synonyms: | N-(2,4-difluorobenzyl)-9'- hydroxy-2'-isopropyl-cis-3- (methoxymethyl)-1',8'-dioxo- 1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazine]- 7'-carboxamide hydrochloride | US10087178, Example S23 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27F2N3O5 | ||
| Mol. Mass. | 475.4851 | ||
| SMILES | COC[C@H]1C[C@@]2(C1)CN(C(C)C)C(=O)c1c(O)c(=O)c(cn21)C(=O)NCc1ccc(F)cc1F |r,wU:5.5,wD:3.2,(7.34,-3.78,;6,-4.55,;4.67,-3.78,;4.67,-2.24,;5.76,-1.15,;4.67,-.07,;3.58,-1.15,;6,.7,;6,2.24,;7.34,3.01,;8.67,2.24,;7.34,4.55,;4.67,3.01,;4.67,4.55,;3.33,2.24,;2,3.01,;2,4.55,;.67,2.24,;-.67,3.01,;.67,.7,;2,-.07,;3.33,.7,;-.67,-.07,;-.67,-1.61,;-2,.7,;-3.33,-.07,;-4.67,.7,;-4.67,2.24,;-6,3.01,;-7.34,2.24,;-8.67,3.01,;-7.34,.7,;-6,-.07,;-6,-1.61,)| | ||
| Structure | 
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