Ki Summary

Reaction Details

Report a problem with these data

Target

Maternal embryonic leucine zipper kinase

Ligand

BDBM177286

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

1.1±n/a nM

Comments

extracted

Citation

Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015

More Info.:

Get all data from this article, Assay Method

Maternal embryonic leucine zipper kinase

Name:

Maternal embryonic leucine zipper kinase

Synonyms:

KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)

Type:

Enzyme

Mol. Mass.:

74665.45

Organism:

Homo sapiens (Human)

Description:

Q14680

Residue:

651

Sequence:

MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV

BDBM177286

n/a

Name

BDBM177286

Synonyms:

US9120749, 652

Type

Small organic molecule

Emp. Form.

C28H31Cl2N3O3

Mol. Mass.

528.47

SMILES

CN(C)C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1 |r,wU:8.11,4.4,wD:4.3,(-4.77,5,;-3.44,4.24,;-2.1,5.01,;-3.44,2.7,;-2.1,1.92,;-2.1,3.46,;-2.1,.38,;-.77,-.38,;.56,.38,;.56,1.92,;-.77,2.69,;1.9,-.39,;1.9,-1.93,;3.23,-2.7,;3.23,-4.24,;1.9,-5.01,;.56,-4.24,;-.77,-5.01,;-2.1,-4.24,;-2.1,-2.7,;-.77,-1.92,;.56,-2.7,;-3.44,-1.93,;-3.44,-.39,;-4.77,.38,;-4.77,1.92,;-6.1,-.39,;-7.44,.38,;-6.1,-1.93,;-7.44,-2.7,;-4.77,-2.7,;4.56,-1.92,;4.56,-.38,;5.9,-2.69,;6.67,-4.03,;7.44,-2.69,)|

Structure