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TargetApoptosis regulator Bcl-2
LigandBDBM177884
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarisation Assay
pH7.4±n/a
IC50 16±n/a nM
Commentsextracted
Citation Le Diguarher, TCasara, PStarck, JHenlin, JDavidson, JEMurray, JBGraham, CJChen, IGeneste, OHickman, JDepil, SLe Tiran, ANyerges, MDe Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9120791 Publication Date 9/1/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:BCL2_MOUSE | Bcl-2 | Bcl2
Type:Protein
Mol. Mass.:26409.44
Organism:Mus musculus (Mouse)
Description:P10417
Residue:236
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM177884
n/a
NameBDBM177884
Synonyms:US9120791, Example 113 | US9603854, 113
TypeSmall organic molecule
Emp. Form.C43H42N4O7
Mol. Mass.726.8162
SMILESOC1CCn2c(C1)c(cc2-c1cc2OCOc2cc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)C(=O)N(c1ccccc1)c1ccc(O)cc1
Structure
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