| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM19422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In-vitro HDAC Enzymatic Endpoint Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 37±n/a nM |
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| IC50 | 41± 12 nM |
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| Comments | extracted |
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| Citation |  Wagner, FF; Lundh, M; Kaya, T; McCarren, P; Zhang, YL; Chattopadhyay, S; Gale, JP; Galbo, T; Fisher, SL; Meier, BC; Vetere, A; Richardson, S; Morgan, NG; Christensen, DP; Gilbert, TJ; Hooker, JM; Leroy, M; Walpita, D; Mandrup-Poulsen, T; Wagner, BK; Holson, EB An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection. ACS Chem Biol11:363-74 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM19422 |
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| n/a |
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| Name | BDBM19422 |
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| Synonyms: | 4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-994 | N-(2-aminophenyl)-4-acetamidobenzamide | N-acetyldinaline | US11207431, Example F | US11377423, CI-994 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N3O2 |
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| Mol. Mass. | 269.2985 |
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| SMILES | CC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N |
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| Structure | 
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