| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM178096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In-vitro HDAC Enzymatic Endpoint Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 8.67e+3± 2.94e+3 nM |
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| Comments | extracted |
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| Citation |  Wagner FF; Lundh M; Kaya T; McCarren P; Zhang YL; Chattopadhyay S; Gale JP; Galbo T; Fisher SL; Meier BC; Vetere A; Richardson S; Morgan NG; Christensen DP; Gilbert TJ; Hooker JM; Leroy M; Walpita D; Mandrup-Poulsen T; Wagner BK; Holson EB An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection. ACS Chem Biol 11:363-74 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1/6 |
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| Synonyms: | HD1 | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purified from NIH 3T3 cells harboring human HDAC1 using an anti-FLAG M2 antibody. |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM178096 |
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| n/a |
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| Name | BDBM178096 |
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| Synonyms: | 4-Acetamido-N-(2-amino-5-methylphenyl)benzamide (6) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N3O2 |
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| Mol. Mass. | 283.3251 |
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| SMILES | CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(C)ccc1N |
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| Structure | 
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