| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 3 [N508S] |
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| Ligand | BDBM178102 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PRMT Biochemical Assays |
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| Ki | 550±85 nM |
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| IC50 | 1100±180 nM |
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| Citation |  Eram, MS; Shen, Y; Szewczyk, MM; Wu, H; Senisterra, G; Li, F; Butler, KV; Kaniskan, Hÿ; Speed, BA; Dela Seña, C; Dong, A; Zeng, H; Schapira, M; Brown, PJ; Arrowsmith, CH; Barsyte-Lovejoy, D; Liu, J; Vedadi, M; Jin, J A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol11:772-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 3 [N508S] |
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| Name: | Protein arginine N-methyltransferase 3 [N508S] |
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| Synonyms: | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3) |
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| Type: | Protein |
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| Mol. Mass.: | 59859.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60678[N508S] |
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| Residue: | 531 |
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| Sequence: | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
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| BDBM178102 |
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| n/a |
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| Name | BDBM178102 |
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| Synonyms: | N1-Methyl-N1-((4-(3-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methyl)ethane-1,2-diamine (Compound 2) |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18F3N3 |
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| Mol. Mass. | 297.3187 |
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| SMILES | CN(CCN)Cc1c[nH]cc1-c1cccc(c1)C(F)(F)F |
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| Structure | 
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