Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM178659 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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Ki | 0.01±n/a nM |
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Citation | Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, L; Hexamer, LA; Kunzer, AR; Mantei, RA; McClellan, WJ; Park, CH; Park, C; Petros, AM; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent US9125913 Publication Date 9/8/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | BCL2_MOUSE | Bcl-2 | Bcl2 |
Type: | Protein |
Mol. Mass.: | 26409.44 |
Organism: | Mus musculus (Mouse) |
Description: | P10417 |
Residue: | 236 |
Sequence: | MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM178659 |
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n/a |
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Name | BDBM178659 |
Synonyms: | US9125913, 225 |
Type | Small organic molecule |
Emp. Form. | C48H54ClN7O8S |
Mol. Mass. | 924.502 |
SMILES | OC1CCC(=C(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCN(CC4)C4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3ccc4[nH]ccc4c3)c2)C1)c1ccc(Cl)cc1 |t:4| |
Structure |
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