Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetApoptosis regulator Bcl-2
LigandBDBM178868
Substrate/Competitorn/a
Meas. Tech.Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Ki<0.010±n/a nM
Citation Bruncko, MDing, HDoherty, GAElmore, SWHasvold, LHexamer, LAKunzer, ARMantei, RAMcClellan, WJPark, CHPark, CPetros, AMSong, XSouers, AJSullivan, GMTao, ZWang, GTWang, LWang, XWendt, MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent US9125913 Publication Date 9/8/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:BCL2_MOUSE | Bcl-2 | Bcl2
Type:Protein
Mol. Mass.:26409.44
Organism:Mus musculus (Mouse)
Description:P10417
Residue:236
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPA
VHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTP
FTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR
HLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM178868
n/a
NameBDBM178868
Synonyms:US9125913, 440
TypeSmall organic molecule
Emp. Form.C47H54ClN7O7S
Mol. Mass.896.492
SMILESCOC1CCC(CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cccc3[nH]cnc23)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(Cl)cc3)CC2)CC1 |t:48,(-10.74,-10.44,;-9.2,-10.44,;-8.43,-9.1,;-6.89,-9.1,;-6.12,-7.77,;-6.89,-6.44,;-6.12,-5.1,;-6.89,-3.77,;-6.12,-2.44,;-4.58,-2.44,;-3.81,-1.1,;-4.58,.23,;-6.12,.23,;-6.89,-1.1,;-8.43,-1.1,;-9.2,.23,;-9.2,-2.44,;-3.81,1.56,;-5.15,2.33,;-3.04,2.9,;-2.48,.79,;-1.15,1.56,;-1.15,3.1,;.19,.79,;1.52,1.56,;2.86,.79,;2.86,-.75,;1.52,-1.52,;.19,-.75,;-1.15,-1.52,;-1.15,-3.06,;.19,-3.83,;.19,-5.37,;-1.15,-6.14,;-2.48,-5.37,;-3.94,-5.84,;-4.85,-4.6,;-3.94,-3.35,;-2.48,-3.83,;4.19,-1.52,;5.52,-.75,;6.86,-1.52,;6.86,-3.06,;8.19,-3.83,;9.52,-3.06,;10.86,-3.83,;12.19,-3.06,;12.19,-1.52,;13.73,-1.46,;13.01,-.21,;10.86,-.75,;9.52,-1.52,;10.86,-5.37,;12.19,-6.14,;12.19,-7.68,;10.86,-8.45,;10.86,-9.99,;9.52,-7.68,;9.52,-6.14,;5.52,-3.83,;4.19,-3.06,;-8.43,-6.44,;-9.2,-7.77,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: