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TargetApoptosis regulator Bcl-XL
LigandBDBM21447
Substrate/Competitorn/a
Meas. Tech.Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Ki 0.08±n/a nM
Citation Bruncko MDing HDoherty GAElmore SWHasvold LHexamer LAKunzer ARMantei RAMcClellan WJPark CHPark CPetros AMSong XSouers AJSullivan GMTao ZWang GTWang LWang XWendt MD Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases US Patent  US9125913 Publication Date 9/8/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-XL
Name:Apoptosis regulator Bcl-XL
Synonyms:n/a
Type:Protein
Mol. Mass.:26122.63
Organism:Mus musculus (Mouse)
Description:Q64373
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEP
WIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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  Blast E-value cutoff:
BDBM21447
n/a
NameBDBM21447
Synonyms:4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide | ABT-737 | CHEMBL376408 | N-Benylpiperazine derivative, 2 | US9125913, ABT-737
TypeSmall organic molecule
Emp. Form.C42H45ClN6O5S2
Mol. Mass.813.427
SMILESCN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r|
Structure
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