| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein O-GlcNAcase |
|---|
| Ligand | BDBM179366 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| pH | 7±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 0.26±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Selnick, HG; Liu, K; McEachern, EJ; Zhou, Y; Zhu, Y Selective glycosidase inhibitors and uses thereof US Patent US9126957 Publication Date 9/8/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein O-GlcNAcase |
|---|
| Name: | Protein O-GlcNAcase |
|---|
| Synonyms: | 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | OGA | OGA_HUMAN | Protein O-GlcNAcase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 102874.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60502 |
|---|
| Residue: | 916 |
|---|
| Sequence: | MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
|
|
|
|---|
| BDBM179366 |
|---|
| n/a |
|---|
| Name | BDBM179366 |
|---|
| Synonyms: | US9126957, 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H20N2O4 |
|---|
| Mol. Mass. | 244.2875 |
|---|
| SMILES | C[C@H](O)[C@H]1C[C@@H]2OC(=N[C@@H]2[C@@H](O)[C@@H]1O)N(C)C |c:7| |
|---|
| Structure | 
|
|---|
Search and Browse
