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TargetHematopoietic prostaglandin D synthase
LigandBDBM179382
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Binding Assay (FPBA)
Temperature298.15±n/a K
IC50 450±n/a nM
Commentsextracted
Citation Endres, GWLee, PHOlson, KLKramer, JBCiske, FLBarrett, SD Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases US Patent US9126973 Publication Date 9/8/2015
More Info.:Get all data from this article,  Assay Method
 
Hematopoietic prostaglandin D synthase
Name:Hematopoietic prostaglandin D synthase
Synonyms:GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM179382
n/a
NameBDBM179382
Synonyms:US9126973, 4
TypeSmall organic molecule
Emp. Form.C20H16N4
Mol. Mass.312.3678
SMILESCc1nc([nH]c1-c1cnc(nc1)-c1ccccc1)-c1ccccc1
Structure
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