| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of Hepatocyte growth factor receptor (2) |
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| Ligand | BDBM60590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | c-Met Z-LYTE Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 13±n/a nM |
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| Comments | extracted |
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| Citation |  Liu, N; Wang, Y; Huang, G; Ji, C; Fan, W; Li, H; Cheng, Y; Tian, H Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors. Bioorg Chem65:146-58 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of Hepatocyte growth factor receptor (2) |
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| Name: | Isoform 2 of Hepatocyte growth factor receptor (2) |
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| Synonyms: | Hepatocyte growth factor receptor (2) | Hepatocyte growth factor receptor (HGFR) | MET | MET_HUMAN | Tyrosine kinase receptor c-Met (c-Met) |
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| Type: | Protein |
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| Mol. Mass.: | 157730.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08581-2 |
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| Residue: | 1408 |
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| Sequence: | MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISTWWKEPLNIVSFLFCFASGGSTITG
VGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFM
LDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSIS
TALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVD
YRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPEL
VQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVS
QFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI
GFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTG
AKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRL
LQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCV
APYPSLLSSEDNADDEVDTRPASFWETS
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| BDBM60590 |
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| n/a |
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| Name | BDBM60590 |
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| Synonyms: | 6-(1-{6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl}cyclopropyl)quinoline (5) |
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| Type | n/a |
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| Emp. Form. | C22H16N6 |
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| Mol. Mass. | 364.4026 |
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| SMILES | C1CC1(c1nnc2ncc(nn12)-c1ccccc1)c1ccc2ncccc2c1 |
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| Structure | 
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