| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor [538-972] |
|---|
| Ligand | BDBM181027 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 303.15±n/a K |
|---|
| IC50 | 5±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Flynn, DL; Kaufman, MD; Samarakoon, T; Caldwell, TM; Vogeti, L; Ahn, Y; Patt, WC; Yates, KM Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities US Patent US9133183 Publication Date 9/15/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage colony-stimulating factor 1 receptor [538-972] |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor [538-972] |
|---|
| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Proto-oncogene c-Fms | cFMS |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 48843.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant protein contains the full-length FMS cytoplasmic domain (FMS538-972.6His). |
|---|
| Residue: | 435 |
|---|
| Sequence: | YKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVV
EATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG
PVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSS
QGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR
DVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSD
VWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEP
THRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQG
DIAQPLLQPNNYQFC
|
|
|
|---|
| BDBM181027 |
|---|
| n/a |
|---|
| Name | BDBM181027 |
|---|
| Synonyms: | US9133183, Example 90 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H24N6O4 |
|---|
| Mol. Mass. | 412.4424 |
|---|
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)C(C)(C)C)nc2)ccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
