| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM181016 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.5±n/a |
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| Ki | <10±0.0 nM |
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| Comments | extracted |
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| Citation |  Hollick, JJ; Jones, SD; Flynn, CJ; Thomas, MG Pyrimidine derivatives as protein kinase inhibitors US Patent US9133199 Publication Date 9/15/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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| BDBM181016 |
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| n/a |
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| Name | BDBM181016 |
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| Synonyms: | US9133199, I-253 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H35N7O3 |
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| Mol. Mass. | 505.6119 |
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| SMILES | COc1cc(ccc1Nc1ncc2N(C)C(=O)C3(CC3)CN(C3CCCC3)c2n1)C(=O)NN1CCCC1 |
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| Structure | 
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