| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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| Ligand | BDBM50214969 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FabZ Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 7.7e+3± 2.0e+3 nM |
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| Comments | extracted |
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| Citation |  McGillick, BE; Kumaran, D; Vieni, C; Swaminathan, S ß-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies. Biochemistry55:1091-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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| Name: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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| Synonyms: | beta-Hydroxyacyl-acyl carrier protein dehydratase (FtFabZ) |
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| Type: | Protein |
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| Mol. Mass.: | 18151.57 |
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| Organism: | Francisella tularensis |
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| Description: | n/a |
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| Residue: | 163 |
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| Sequence: | MSQFNQNNKQIDVMGIRKILPHRYPFALLDKIVDWSVEDRTIVAQKNVTINEDFFNGHFP
DFPVMPGVLIVEAMAQATAILGELMAETLFAHVVEKAGGGRRTFMLAGIDKVRVKRPVVP
GDVLVIESRMVKQKNIICTAESVAKVDGQIVCSAELMAAYKDY
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| BDBM50214969 |
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| n/a |
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| Name | BDBM50214969 |
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| Synonyms: | 1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2-enyl)-xanthen-9-one | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone | CHEMBL323197 | Mangostin | alpha-mangostin |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26O6 |
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| Mol. Mass. | 410.4596 |
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| SMILES | [#6]-[#8]-c1c(-[#8])cc2oc3cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c3c(=O)c2c1-[#6]\[#6]=[#6](\[#6])-[#6] |
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| Structure | 
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