Reaction Details |
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Target | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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Ligand | BDBM11318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FabZ Inhibition Assay |
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pH | 7±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 4.31e+4± 9.2e+3 nM |
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Comments | extracted |
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Citation | McGillick, BE; Kumaran, D; Vieni, C; Swaminathan, S ß-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies. Biochemistry55:1091-9 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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Name: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
Synonyms: | beta-Hydroxyacyl-acyl carrier protein dehydratase (FtFabZ) |
Type: | Protein |
Mol. Mass.: | 18151.57 |
Organism: | Francisella tularensis |
Description: | n/a |
Residue: | 163 |
Sequence: | MSQFNQNNKQIDVMGIRKILPHRYPFALLDKIVDWSVEDRTIVAQKNVTINEDFFNGHFP
DFPVMPGVLIVEAMAQATAILGELMAETLFAHVVEKAGGGRRTFMLAGIDKVRVKRPVVP
GDVLVIESRMVKQKNIICTAESVAKVDGQIVCSAELMAAYKDY
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BDBM11318 |
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n/a |
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Name | BDBM11318 |
Synonyms: | 1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione | 1,3,8-trihydroxy-6-methylanthra-9,10-quinone | CHEMBL289277 | Emodin | US20230364057, Compound 242 | med.21724, Compound 24 |
Type | Small organic molecule |
Emp. Form. | C15H10O5 |
Mol. Mass. | 270.2369 |
SMILES | Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 |
Structure |
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