| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM181619 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In vitro Kinase Assay |
|---|
| IC50 | 1±n/a nM |
|---|
| Citation |  Blum, A; Gottschling, D; Heckel, A; Hehn, JP; Schmid, B; Wiedenmayer, D Sulfoximine substituted quinazolines for pharmaceutical compositions US Patent US9139577 Publication Date 9/22/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51870.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBH9 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
|
|
|
|---|
| BDBM181619 |
|---|
| n/a |
|---|
| Name | BDBM181619 |
|---|
| Synonyms: | US9139577, 4.125 | US9708274, 4.125 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26ClF2N5O3S |
|---|
| Mol. Mass. | 538.01 |
|---|
| SMILES | CC(NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
