Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM181730 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Electrophysiology Assay |
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pH | 7.4±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 71±n/a nM |
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Comments | extracted |
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Citation | Walsh, SP; Pasternak, A; DeJesus, RK; Tang, H; Pio, B; Shahripour, A; Belyk, KM; Chobanian, HR; Guo, Y; Frie, JL; Shi, Z; Chen, H; Blizzard, TA; Cato, B Inhibitors of the Renal Outer Medullary Potassium channel US Patent US9139585 Publication Date 9/22/2015 |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44809.08 |
Organism: | Homo sapiens (Human) |
Description: | gi_223460826 |
Residue: | 391 |
Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM181730 |
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n/a |
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Name | BDBM181730 |
Synonyms: | US9139585, 25 | US9139585, 26 |
Type | Small organic molecule |
Emp. Form. | C26H30N4O6 |
Mol. Mass. | 494.5396 |
SMILES | COc1cc(ncc1[N+]#[C-])C(O)CN1C2COCC1CN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2 |r,THB:21:20:13:15.17.16| |
Structure |
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