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TargetProstaglandin E synthase 2
LigandBDBM181980
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
pH6.8±n/a
IC50 81±n/a nM
Commentsextracted
Citation Bylund, JEk, MEGravenfors, YNordvall, GMinidis, AVallin, KSViklund, JHolenz, JVon Berg, SSohn, D Bis-(sulfonylamino) derivatives for use in therapy US Patent US9145380 Publication Date 9/29/2015
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase 2
Name:Prostaglandin E synthase 2
Synonyms:C9orf15 | PGES2 | PGES2_HUMAN | PTGES2
Type:Enzyme
Mol. Mass.:41955.21
Organism:Homo sapiens (Human)
Description:Q9H7Z7
Residue:377
Sequence:
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLG
AAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFL
DFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD
WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQ
DNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQ
PWYLRVERAITEASPAH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM181980
n/a
NameBDBM181980
Synonyms:US9145380, 183
TypeSmall organic molecule
Emp. Form.C20H24N2O4S2
Mol. Mass.420.546
SMILESCC(C)(C)C#Cc1ccc(CCS(=O)(=O)Nc2ccccc2S(N)(=O)=O)cc1
Structure
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