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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM182062 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
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| BDBM182062 | |||
| n/a | |||
| Name | BDBM182062 | ||
| Synonyms: | US9145391, 1-30 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29F3N4O3 | ||
| Mol. Mass. | 514.5394 | ||
| SMILES | CCC(O)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(C)cc(Nc2cc(ccn2)C(F)(F)F)n1 |(-4.98,1.8,;-3.08,1.8,;-1.95,-.26,;-1.18,1.08,;-.41,-.26,;.36,1.08,;1.9,1.08,;2.73,-.26,;1.9,-1.59,;.36,-1.59,;4.27,-.26,;5.04,-1.59,;5.04,1.08,;-1.95,-1.8,;-.62,-2.57,;-.62,-4.11,;-1.95,-4.88,;-3.28,-4.11,;-3.28,-2.57,;-1.95,-6.42,;-.62,-7.19,;-.62,-8.73,;.72,-9.5,;-1.95,-9.5,;-3.28,-8.73,;-4.62,-9.5,;-5.95,-8.73,;-5.95,-7.19,;-7.28,-6.42,;-8.62,-7.19,;-8.62,-8.73,;-7.28,-9.5,;-7.28,-4.88,;-8.62,-4.11,;-6.89,-3.39,;-5.8,-5.28,;-3.28,-7.19,)| | ||
| Structure | 
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