Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase SYK

Ligand

BDBM182065

Substrate/Competitor

n/a

Meas. Tech.

Homogeneous Time-Resolved Fluorescence (HTRF) Assay

7.5±n/a

Temperature

298.15±n/a K

IC50

<0.5±n/a nM

Comments

extracted

Citation

Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase SYK

Name:

Tyrosine-protein kinase SYK

Synonyms:

KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)

Type:

Enzyme

Mol. Mass.:

72079.99

Organism:

Homo sapiens (Human)

Description:

P43405

Residue:

635

Sequence:

MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN

BDBM182065

n/a

Name

BDBM182065

Synonyms:

US9145391, 1-33

Type

Small organic molecule

Emp. Form.

C28H30F2N4O3

Mol. Mass.

508.5596

SMILES

CC(O)(C1CCC(CC1)C(O)=O)c1ccc(cn1)-c1cc(cc(Nc2cc(ccn2)C(F)F)n1)C1CC1 |(-3.1,1.33,;-2.33,,;-1.56,1.33,;-.79,,;-.02,1.33,;1.52,1.33,;2.34,,;1.52,-1.33,;-.02,-1.33,;3.88,-0,;4.65,-1.33,;4.65,1.33,;-2.33,-1.54,;-1,-2.31,;-1,-3.85,;-2.33,-4.62,;-3.67,-3.85,;-3.67,-2.31,;-2.33,-6.16,;-1,-6.93,;-1,-8.47,;-2.33,-9.24,;-3.67,-8.47,;-5,-9.24,;-6.34,-8.47,;-6.34,-6.93,;-7.67,-6.16,;-9,-6.93,;-9,-8.47,;-7.67,-9.24,;-7.67,-4.62,;-9,-3.85,;-6.67,-3.68,;-3.67,-6.93,;.33,-9.24,;.33,-10.78,;1.87,-9.24,)|

Structure