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TargetTyrosine-protein kinase SYK
LigandBDBM182147
Substrate/Competitorn/a
Meas. Tech.Homogeneous Time-Resolved Fluorescence (HTRF) Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50<0.5±n/a nM
Commentsextracted
Citation Deschenes, DAltman, MDEllis, JMFischer, CHaidle, AMKattar, SDNorthrup, ABSchell, AJSmith, GFTaoka, BMBienstock, CDi Francesco, MEDonofrio, APeterson, SSpencer, KBJewell, JPAli, ABennett, DJDang, QWai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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  Blast E-value cutoff:
BDBM182147
n/a
NameBDBM182147
Synonyms:US9145391, 4-44
TypeSmall organic molecule
Emp. Form.C31H27F3N8O
Mol. Mass.584.5943
SMILESCc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1ccc(NC2CCN(CC2)C(=O)c2ccc3cccnc3n2)nc1
Structure
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