Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM182241 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
| ||
| BDBM182241 | |||
| n/a | |||
| Name | BDBM182241 | ||
| Synonyms: | US9145391, 13 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27F3N4O2 | ||
| Mol. Mass. | 484.5134 | ||
| SMILES | Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(F)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:29.35,wD:26.28,(2.67,-6.93,;1.33,-6.16,;,-6.93,;-1.33,-6.16,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-3.79,;-6.67,-4.62,;-6.67,-6.16,;-5.33,-6.93,;-5.33,-2.25,;-6.67,-1.48,;-4,-1.48,;-1.33,-4.62,;,-3.85,;1.33,-4.62,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;1.33,,;1.33,-1.54,;,2.31,;-1.33,1.54,;-1.33,3.08,;1.33,3.08,;2.67,2.31,;4,3.08,;4,4.62,;2.67,5.39,;1.33,4.62,;5.33,5.39,;6.67,4.62,;5.33,6.93,)| | ||
| Structure | 
| ||