Reaction Details | |||
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Target | Tyrosine-protein kinase SYK | ||
Ligand | BDBM182244 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | <0.5±n/a nM | ||
Comments | extracted | ||
Citation | Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 Publication Date 9/29/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase SYK | |||
Name: | Tyrosine-protein kinase SYK | ||
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
Type: | Enzyme | ||
Mol. Mass.: | 72079.99 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P43405 | ||
Residue: | 635 | ||
Sequence: |
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BDBM182244 | |||
n/a | |||
Name | BDBM182244 | ||
Synonyms: | US9145391, 16 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H27F2N4O3 | ||
Mol. Mass. | 481.5149 | ||
SMILES | Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(nc1)C(C)(O)[C@H]1CC[C@@H](CC1)C([O-])=O |r,wU:29.35,wD:26.28,(4.71,-1.94,;3.38,-1.17,;3.38,.37,;2.04,1.14,;2.04,2.68,;3.38,3.45,;3.38,4.99,;4.71,5.76,;6.05,4.99,;6.05,3.45,;4.71,2.68,;4.71,7.3,;3.38,8.07,;6.05,8.07,;.71,.37,;.71,-1.17,;2.04,-1.94,;-.62,-1.94,;-1.96,-1.17,;-3.29,-1.94,;-3.29,-3.48,;-1.96,-4.25,;-.62,-3.48,;-4.62,-4.25,;-5.39,-2.91,;-3.85,-5.58,;-5.96,-5.02,;-7.29,-4.25,;-8.63,-5.02,;-8.63,-6.56,;-7.29,-7.33,;-5.96,-6.56,;-9.96,-7.33,;-9.96,-8.87,;-11.29,-6.56,)| | ||
Structure |