| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 |
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| Ligand | BDBM182588 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P70S6K Enzyme Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.8±n/a nM |
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| Comments | extracted |
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| Citation |  Lan, R; Huck, BR; Xiao, Y; Chen, X; Deselm, LC; Qiu, H; Neagu, C; Bankston, D; Jones, CC Imidazole amines as modulators of kinase activity US Patent US9145392 Publication Date 9/29/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 |
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| Name: | Ribosomal protein S6 kinase beta-1 |
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| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59139.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | His-tagged S6K1. |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM182588 |
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| n/a |
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| Name | BDBM182588 |
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| Synonyms: | US9145392, 289 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33ClFN7O |
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| Mol. Mass. | 514.038 |
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| SMILES | CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1 |
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| Structure | 
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