| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 |
|---|
| Ligand | BDBM182615 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | P70S6K Enzyme Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 0.8±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Lan, R; Huck, BR; Xiao, Y; Chen, X; Deselm, LC; Qiu, H; Neagu, C; Bankston, D; Jones, CC Imidazole amines as modulators of kinase activity US Patent US9145392 Publication Date 9/29/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ribosomal protein S6 kinase beta-1 |
|---|
| Name: | Ribosomal protein S6 kinase beta-1 |
|---|
| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59139.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | His-tagged S6K1. |
|---|
| Residue: | 525 |
|---|
| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
|
|
|
|---|
| BDBM182615 |
|---|
| n/a |
|---|
| Name | BDBM182615 |
|---|
| Synonyms: | US9145392, 316 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29F3N8 |
|---|
| Mol. Mass. | 510.5573 |
|---|
| SMILES | Cc1ccc(cc1C(F)(F)F)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N |
|---|
| Structure | 
|
|---|
Search and Browse
