| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 2 |
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| Ligand | BDBM182852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 600±n/a nM |
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| Citation |  Chang, T; Chang, CC; Shibuya, Y; Bryleva, E; Murphy, S; Rogers, MA Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease US Patent US9149492 Publication Date 10/6/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 2 |
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| Name: | Sterol O-acyltransferase 2 |
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| Synonyms: | ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 59912.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75908 |
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| Residue: | 522 |
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| Sequence: | MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
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| BDBM182852 |
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| n/a |
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| Name | BDBM182852 |
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| Synonyms: | US9149492, Compound 1D |
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| Type | Small organic molecule |
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| Emp. Form. | C38H46N2O5 |
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| Mol. Mass. | 610.7822 |
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| SMILES | CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(OC(=O)CN2CCCCCC2=O)cc1 |
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| Structure | 
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