Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGlycylpeptide N-tetradecanoyltransferase 1
LigandBDBM185101
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 4±n/a nM
Commentsextracted
Citation Brand, SWyatt, PThompson, SSmith, VBayliss, THarrison, JNorcross, NCleghorn, LGilbert, IBrenk, R N-myristoyl transferase inhibitors US Patent US9156811 Publication Date 10/13/2015
More Info.:Get all data from this article,  Assay Method
 
Glycylpeptide N-tetradecanoyltransferase 1
Name:Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:Enzyme
Mol. Mass.:56814.10
Organism:Homo sapiens (Human)
Description:P30419
Residue:496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM185101
n/a
NameBDBM185101
Synonyms:US9156811, DDD100807
TypeSmall organic molecule
Emp. Form.C22H30Cl2F2N4O2S
Mol. Mass.523.467
SMILESCc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: