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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ferrochelatase, mitochondrial [R115L] | ||
| Ligand | BDBM185145 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Competition Binding Assays | ||
| Kd | 4.4e+3±n/a nM | ||
| Citation |  Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ferrochelatase, mitochondrial [R115L] | |||
| Name: | Ferrochelatase, mitochondrial [R115L] | ||
| Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 47832.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Mutant R115L used for experiment | ||
| Residue: | 423 | ||
| Sequence: |
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| BDBM185145 | |||
| n/a | |||
| Name | BDBM185145 | ||
| Synonyms: | 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine | AEW-541 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29N5O | ||
| Mol. Mass. | 439.5521 | ||
| SMILES | Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)C1CC(CN2CCC2)C1 |(4.47,1.16,;4.47,-.38,;3.14,-1.15,;3.14,-2.69,;4.47,-3.46,;5.81,-2.69,;7.27,-3.16,;8.16,-1.92,;7.27,-.68,;7.74,.79,;9.25,1.1,;9.73,2.57,;8.7,3.71,;7.19,3.4,;6.17,4.54,;6.64,6.01,;5.62,7.15,;6.09,8.62,;5.07,9.76,;3.56,9.44,;3.08,7.98,;4.11,6.83,;6.72,1.93,;5.81,-1.15,;7.74,-4.62,;9.12,-5.32,;8.42,-6.69,;8.9,-8.15,;10.41,-8.47,;11.25,-9.76,;12.54,-8.92,;11.7,-7.63,;7.05,-5.99,)| | ||
| Structure | 
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