| Reaction Details |
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 | Report a problem with these data |
| Target | Ferrochelatase, mitochondrial [R115L] |
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| Ligand | BDBM25117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assays |
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| Kd | 3.1e+3±n/a nM |
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| Citation |  Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ferrochelatase, mitochondrial [R115L] |
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| Name: | Ferrochelatase, mitochondrial [R115L] |
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| Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47832.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Mutant R115L used for experiment |
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| Residue: | 423 |
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| Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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| BDBM25117 |
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| n/a |
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| Name | BDBM25117 |
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| Synonyms: | AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide | US10464902, Axitinib | US9205078, Axitinib | US9617222, Compound A |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4OS |
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| Mol. Mass. | 386.47 |
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| SMILES | CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 |
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| Structure | 
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