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TargetFerrochelatase, mitochondrial [R115L]
LigandBDBM185149
Substrate/Competitorn/a
Meas. Tech.Competition Binding Assays
Kd 3.8e+3±n/a nM
Citation Klaeger, SGohlke, BPerrin, JGupta, VHeinzlmeir, SHelm, DQiao, HBergamini, GHanda, HSavitski, MMBantscheff, MMédard, GPreissner, RKuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ferrochelatase, mitochondrial [R115L]
Name:Ferrochelatase, mitochondrial [R115L]
Synonyms:FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN
Type:Protein
Mol. Mass.:47832.73
Organism:Homo sapiens (Human)
Description:Mutant R115L used for experiment
Residue:423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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  Blast E-value cutoff:
BDBM185149
n/a
NameBDBM185149
Synonyms:1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine | Crenolanib | US11542261, Compound crenolanib
TypeSmall organic molecule
Emp. Form.C26H29N5O2
Mol. Mass.443.5408
SMILESCC1(COc2ccc3n(cnc3c2)-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1
Structure
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