Reaction Details |
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Target | Ferrochelatase, mitochondrial [R115L] |
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Ligand | BDBM50331094 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Competition Binding Assays |
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Kd | 3.1e+3±n/a nM |
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Citation | Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol11:1245-54 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ferrochelatase, mitochondrial [R115L] |
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Name: | Ferrochelatase, mitochondrial [R115L] |
Synonyms: | FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN |
Type: | Protein |
Mol. Mass.: | 47832.73 |
Organism: | Homo sapiens (Human) |
Description: | Mutant R115L used for experiment |
Residue: | 423 |
Sequence: | MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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BDBM50331094 |
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n/a |
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Name | BDBM50331094 |
Synonyms: | 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide | 4-(3-chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide | CHEMBL1289601 | E-7080 | Lenvatinib mesilate | Lenvima | lenvatinib |
Type | Small organic molecule |
Emp. Form. | C21H19ClN4O4 |
Mol. Mass. | 426.853 |
SMILES | COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O |
Structure |
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