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TargetFerrochelatase R115L (FECH)
LigandBDBM50311017
Substrate/Competitorn/a
Meas. Tech.Competition Binding Assays
Kd 3.4e+3± 0 nM
Citation Klaeger SGohlke BPerrin JGupta VHeinzlmeir SHelm DQiao HBergamini GHanda HSavitski MMBantscheff MMédard GPreissner RKuster B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol 11:1245-54 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ferrochelatase R115L (FECH)
Name:Ferrochelatase R115L (FECH)
Synonyms:n/a
Type:Protein
Mol. Mass.:47832.73
Organism:Homo sapiens (Human)
Description:Mutant R115L used for experiment
Residue:423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50311017
n/a
NameBDBM50311017
Synonyms:CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide | US10112907, Example 00019 | US9469613, CYT-0387
TypeSmall organic molecule
Emp. Form.C23H22N6O2
Mol. Mass.414.4598
SMILESO=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Structure
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