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TargetFerrochelatase R115L (FECH)
LigandBDBM185151
Substrate/Competitorn/a
Meas. Tech.Competition Binding Assays
Kd 4.5e+3± 0 nM
Citation Klaeger SGohlke BPerrin JGupta VHeinzlmeir SHelm DQiao HBergamini GHanda HSavitski MMBantscheff MMédard GPreissner RKuster B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol 11:1245-54 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ferrochelatase R115L (FECH)
Name:Ferrochelatase R115L (FECH)
Synonyms:n/a
Type:Protein
Mol. Mass.:47832.73
Organism:Homo sapiens (Human)
Description:Mutant R115L used for experiment
Residue:423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQ
EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD
GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH
ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV
WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC
GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS
QQL
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  Blast E-value cutoff:
BDBM185151
n/a
NameBDBM185151
Synonyms:4-[(5Z)-4-amino-5-(7-methoxyindol-2-ylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid | OSI-027
TypeSmall organic molecule
Emp. Form.C21H22N6O3
Mol. Mass.406.4378
SMILESCOc1cccc2=C\C(N=c12)=c1\nc(C2CCC(CC2)C(O)=O)n2NC=NC(N)=c12 |c:28,t:6,9,31,(12.9,-6.58,;11.76,-5.55,;10.29,-6.03,;9.98,-7.54,;8.51,-8.02,;7.37,-6.99,;7.68,-5.48,;6.78,-4.24,;7.68,-3,;9.14,-3.47,;9.15,-5,;7.2,-1.54,;8.1,-.3,;7.2,.94,;7.68,2.4,;6.65,3.55,;7.13,5.01,;8.64,5.33,;9.67,4.18,;9.19,2.72,;9.12,6.79,;10.63,7.11,;8.09,7.94,;5.75,.47,;4.41,1.24,;3.08,.47,;3.08,-1.07,;4.41,-1.84,;4.41,-3.38,;5.75,-1.07,)|
Structure
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