| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XIII A chain [Q652E] |
|---|
| Ligand | BDBM185180 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TG Activity Assays |
|---|
| IC50 | >1.00e+5±n/a nM |
|---|
| Citation |  Badarau, E; Wang, Z; Rathbone, DL; Costanzi, A; Thibault, T; Murdoch, CE; El Alaoui, S; Bartkeviciute, M; Griffin, M Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol22:1347-61 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XIII A chain [Q652E] |
|---|
| Name: | Coagulation factor XIII A chain [Q652E] |
|---|
| Synonyms: | Coagulation factor XIII A (FXIIIa) | F13A | F13A1 | F13A_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83261.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00488[Q652E] |
|---|
| Residue: | 732 |
|---|
| Sequence: | MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
|
|
|
|---|
| BDBM185180 |
|---|
| n/a |
|---|
| Name | BDBM185180 |
|---|
| Synonyms: | [2-[[2-(4-tert-Butoxycarbonylpiperazin-1-yl)-2-oxo-ethyl]amino]-2-oxo-ethyl]-dimethylsulfonium bromide (1m) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H28N3O4S |
|---|
| Mol. Mass. | 346.465 |
|---|
| SMILES | C[S+](C)CC(=O)NCC(=O)N1CCN(CC1)C(=O)OC(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
