| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src [251-533] |
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| Ligand | BDBM185670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinome-Wide Inhibitor Profiling |
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| Kd | 0.53±0.01 nM |
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| Citation |  Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src [251-533] |
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| Name: | Proto-oncogene tyrosine-protein kinase Src [251-533] |
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| Synonyms: | Proto-oncogene tyrosine-protein kinase Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC_CHICK |
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| Type: | Protein |
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| Mol. Mass.: | 32360.42 |
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| Organism: | Gallus gallus (Chicken) |
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| Description: | Wild-type chicken c-Src kinase domain (251-533aa) |
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| Residue: | 283 |
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| Sequence: | QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQE
AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI
ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA
PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES
LHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM185670 |
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| n/a |
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| Name | BDBM185670 |
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| Synonyms: | DAS-DFGO-I | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29F3N8O3S |
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| Mol. Mass. | 626.653 |
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| SMILES | Cc1nc(Nc2ncc(s2)C(=O)Nc2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2)cc(n1)N1CCN(CCO)CC1 |
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| Structure | 
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