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TargetTyrosine-protein kinase ABL1 [229-512]
LigandBDBM185671
Substrate/Competitorn/a
Meas. Tech.Kinome-Wide Inhibitor Profiling
Kd 2.9±0.05 nM
Citation Kwarcinski, FEBrandvold, KRPhadke, SBeleh, OMJohnson, TKMeagher, JLSeeliger, MAStuckey, JASoellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ABL1 [229-512]
Name:Tyrosine-protein kinase ABL1 [229-512]
Synonyms:ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl)
Type:Protein
Mol. Mass.:32850.19
Organism:Homo sapiens (Human)
Description:Human c-Abl kinase domain (229-512aa)
Residue:284
Sequence:
SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS
SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
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  Blast E-value cutoff:
BDBM185671
n/a
NameBDBM185671
Synonyms:DAS-DFGO-II
TypeSmall organic molecule
Emp. Form.C30H31F3N8O3S
Mol. Mass.640.679
SMILESCc1nc(Nc2ncc(s2)C(=O)Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc(n1)N1CCN(CCO)CC1
Structure
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