Reaction Details |
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Target | Tyrosine-protein kinase ABL1 [229-512] |
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Ligand | BDBM185671 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinome-Wide Inhibitor Profiling |
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Kd | 2.9±0.05 nM |
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Citation | Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ABL1 [229-512] |
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Name: | Tyrosine-protein kinase ABL1 [229-512] |
Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl) |
Type: | Protein |
Mol. Mass.: | 32850.19 |
Organism: | Homo sapiens (Human) |
Description: | Human c-Abl kinase domain (229-512aa) |
Residue: | 284 |
Sequence: | SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS
SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
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BDBM185671 |
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n/a |
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Name | BDBM185671 |
Synonyms: | DAS-DFGO-II |
Type | Small organic molecule |
Emp. Form. | C30H31F3N8O3S |
Mol. Mass. | 640.679 |
SMILES | Cc1nc(Nc2ncc(s2)C(=O)Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc(n1)N1CCN(CCO)CC1 |
Structure |
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