| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [229-512] |
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| Ligand | BDBM50237710 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinome-Wide Inhibitor Profiling |
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| Kd | 11±2 nM |
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| Citation |  Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ABL1 [229-512] |
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| Name: | Tyrosine-protein kinase ABL1 [229-512] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl) |
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| Type: | Protein |
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| Mol. Mass.: | 32850.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human c-Abl kinase domain (229-512aa) |
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| Residue: | 284 |
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| Sequence: | SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS
SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
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| BDBM50237710 |
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| n/a |
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| Name | BDBM50237710 |
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| Synonyms: | 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide | AMN 107 | AMN107 | CHEMBL255863 | NILOTINIB | US11649218, Example Nilotinib |
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| Type | Small organic molecule |
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| Emp. Form. | C28H22F3N7O |
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| Mol. Mass. | 529.5158 |
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| SMILES | Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F |
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| Structure | 
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