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TargetProto-oncogene tyrosine-protein kinase Src [251-533]
LigandBDBM185676
Substrate/Competitorn/a
Meas. Tech.End Point Fluorescence Assay
pH8±n/a
Kd 2.8±0.0 nM
Commentsextracted
Citation Kwarcinski, FEBrandvold, KRPhadke, SBeleh, OMJohnson, TKMeagher, JLSeeliger, MAStuckey, JASoellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proto-oncogene tyrosine-protein kinase Src [251-533]
Name:Proto-oncogene tyrosine-protein kinase Src [251-533]
Synonyms:Proto-oncogene tyrosine-protein kinase Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC_CHICK
Type:Protein
Mol. Mass.:32360.42
Organism:Gallus gallus (Chicken)
Description:Wild-type chicken c-Src kinase domain (251-533aa)
Residue:283
Sequence:
QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQE
AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI
ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA
PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES
LHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM185676
n/a
NameBDBM185676
Synonyms:DAS-DFGO-II-BODIPY
TypeSmall organic molecule
Emp. Form.C42H40BF5N10O3S
Mol. Mass.870.7
SMILESCc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C)nc(C)n3)=[N+]1[B-]2(F)F |c:10,63,t:8|
Structure
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